Upregulation of Protein Synthesis and Proteasome Degradation Confers Sensitivity to Proteasome Inhibitor Bortezomib in Myc-Atypical Teratoid/Rhabdoid Tumors

Upregulation of Protein Synthesis and Proteasome Degradation Confers Sensitivity to Proteasome Inhibitor Bortezomib in Myc-Atypical Teratoid/Rhabdoid Tumors

Atypical teratoid rhabdoid tumors (ATRTs) are among the most malignant brain tumors in early childhood and remain incurable. Myc-ATRT is driven by the <i>Myc</i> oncogene, which directly controls the intracellular protein synthesis rate. Proteasome inhibitor bortezomib (BTZ) was approved...

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Bibliographic Details
Main Authors: Huy Minh Tran, Kuo-Sheng Wu, Shian-Ying Sung, Chun Austin Changou, Tsung-Han Hsieh, Yun-Ru Liu, Yen-Lin Liu, Min-Lan Tsai, Hsin-Lun Lee, Kevin Li-Chun Hsieh, Wen-Chang Huang, Muh-Lii Liang, Hsin-Hung Chen, Yi-Yen Lee, Shih-Chieh Lin, Donald Ming-Tak Ho, Feng-Chi Chang, Meng-En Chao, Wan Chen, Shing-Shung Chu, Alice L. Yu, Yun Yen, Che-Chang Chang, Tai-Tong Wong
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cancers
Subjects:
myc-atrts
protein synthesis
proteasome degradation
bortezomib
p53
Online Access:https://www.mdpi.com/2072-6694/12/3/752

Internet

https://www.mdpi.com/2072-6694/12/3/752

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