Inhibition of NF-κB in astrocytes is sufficient to delay neurodegeneration induced by proteotoxicity in neurons

Inhibition of NF-κB in astrocytes is sufficient to delay neurodegeneration induced by proteotoxicity in neurons

Abstract Background Most neurodegenerative diseases associated with protein aggregation are hallmarked by activation of astrocytes. However, how astrocytes are activated or which signaling pathways in astrocytes contribute to pathogenesis is not clear. One long-standing question is whether the respo...

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Bibliographic Details
Main Authors: Y. X. Li, O. C. M. Sibon, P. F. Dijkers
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Journal of Neuroinflammation
Subjects:
Neurodegeneration
Astrocytes
NF-κB
Cell-non-autonomous
Drosophila
Polyglutamine diseases
Online Access:http://link.springer.com/article/10.1186/s12974-018-1278-2

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http://link.springer.com/article/10.1186/s12974-018-1278-2

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