Synthetic Light-Activated Ion Channels for Optogenetic Activation and Inhibition

Synthetic Light-Activated Ion Channels for Optogenetic Activation and Inhibition

Optogenetic manipulation of cells or living organisms became widely used in neuroscience following the introduction of the light-gated ion channel channelrhodopsin-2 (ChR2). ChR2 is a non-selective cation channel, ideally suited to depolarize and evoke action potentials in neurons. However, its calc...

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Bibliographic Details
Main Authors: Sebastian Beck, Jing Yu-Strzelczyk, Dennis Pauls, Oana M. Constantin, Christine E. Gee, Nadine Ehmann, Robert J. Kittel, Georg Nagel, Shiqiang Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Neuroscience
Subjects:
optogenetics
calcium
potassium
cAMP
bPAC
CNG channel
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2018.00643/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2018.00643/full

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