Butyrate Conditions Human Dendritic Cells to Prime Type 1 Regulatory T Cells via both Histone Deacetylase Inhibition and G Protein-Coupled Receptor 109A Signaling

Butyrate Conditions Human Dendritic Cells to Prime Type 1 Regulatory T Cells via both Histone Deacetylase Inhibition and G Protein-Coupled Receptor 109A Signaling

Recently, it has become clear that short-chain fatty acids (SCFAs), and in particular butyrate, have anti-inflammatory properties. Murine studies have shown that butyrate can promote regulatory T cells via the induction of tolerogenic dendritic cells (DCs). However, the effects of SCFAs on human DCs...

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Bibliographic Details
Main Authors: Maria M. M. Kaisar, Leonard R. Pelgrom, Alwin J. van der Ham, Maria Yazdanbakhsh, Bart Everts
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Immunology
Subjects:
short-chain fatty acids
butyrate
dendritic cells
type 1 regulatory T cells
histone deacetylases
G-coupled protein receptor 109A
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01429/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01429/full

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