Stabilization of HIF-1α in Human Retinal Endothelial Cells Modulates Expression of miRNAs and Proangiogenic Growth Factors

Stabilization of HIF-1α in Human Retinal Endothelial Cells Modulates Expression of miRNAs and Proangiogenic Growth Factors

Retinal hypoxia is one of the causative factors of diabetic retinopathy and is also one of the triggers of VEGF release. We hypothesized that specific dysregulated miRNAs in diabetic retinopathy could be linked to hypoxia-induced damage in human retinal endothelial cells (HRECs). We investigated in...

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Bibliographic Details
Main Authors: Francesca Lazzara, Maria Consiglia Trotta, Chiara Bianca Maria Platania, Michele D’Amico, Francesco Petrillo, Marilena Galdiero, Carlo Gesualdo, Settimio Rossi, Filippo Drago, Claudio Bucolo
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Pharmacology
Subjects:
hypoxia-inducible-factor-1α
vascular endothelial growth factor
transforming growth factor beta
retina
diabetic retinopathy
inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.01063/full

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https://www.frontiersin.org/article/10.3389/fphar.2020.01063/full

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