Retromer in Synaptic Function and Pathology

The retromer complex mediates export of select transmembrane proteins from endosomes to the trans-Golgi network (TGN) or to the plasma membrane. Dysfunction of retromer has been linked with slowly progressing neurodegenerative disorders, including Alzheimer’s and Parkinson’s disease (AD and PD). As...

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Bibliographic Details
Main Authors: Lennart Brodin, Oleg Shupliakov
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Synaptic Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fnsyn.2018.00037/full