Photoactivatable Caged Prodrugs of VEGFR-2 Kinase Inhibitors

Photoactivatable Caged Prodrugs of VEGFR-2 Kinase Inhibitors

In this study, we report on the design, synthesis, photokinetic properties and in vitro evaluation of photoactivatable caged prodrugs for the receptor tyrosine kinase VEGFR-2. Highly potent VEGFR-2 inhibitors 1 and 3 were caged by introduction of a photoremovable protecting group (PPG) to yield the...

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Bibliographic Details
Main Authors: Boris Pinchuk, Rebecca Horbert, Alexander Döbber, Lydia Kuhl, Christian Peifer
Format: Article
Language:English
Published: MDPI AG 2016-04-01
Series:Molecules
Subjects:
photoactivatable prodrugs
caging
receptor tyrosine kinase
kinase inhibitors
VEGFR-2
3,4-diarylmaleimides
photoremovable protecting group (PPG)
Online Access:http://www.mdpi.com/1420-3049/21/5/570

Internet

http://www.mdpi.com/1420-3049/21/5/570

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