Increased separase activity and occurrence of centrosome aberrations concur with transformation of MDS.

Increased separase activity and occurrence of centrosome aberrations concur with transformation of MDS.

ESPL1/separase, a cysteine endopeptidase, is a key player in centrosome duplication and mitotic sister chromatid separation. Aberrant expression and/or altered separase proteolytic activity are associated with centrosome amplification, aneuploidy, tumorigenesis and disease progression. Since centros...

Full description

Bibliographic Details
Main Authors: Sabrina Ruppenthal, Helga Kleiner, Florian Nolte, Alice Fabarius, Wolf-Karsten Hofmann, Daniel Nowak, Wolfgang Seifarth
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5784974?pdf=render

Internet

http://europepmc.org/articles/PMC5784974?pdf=render

Similar Items