The Cytolethal Distending Toxin Subunit CdtB of Helicobacter hepaticus Promotes Senescence and Endoreplication in Xenograft Mouse Models of Hepatic and Intestinal Cell Lines

Cytolethal distending toxins (CDTs) are common among pathogenic bacteria of the human and animal microbiota. CDTs exert cytopathic effets, via their active CdtB subunit. No clear description of those cytopathic effects has been reported at the cellular level in the target organs in vivo. In the pres...

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Bibliographic Details
Main Authors: Christelle Péré-Védrenne, Martina Prochazkova-Carlotti, Benoit Rousseau, Wencan He, Lucie Chambonnier, Elodie Sifré, Alice Buissonnière, Pierre Dubus, Francis Mégraud, Christine Varon, Armelle Ménard
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Cellular and Infection Microbiology
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Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2017.00268/full