Disruption of microRNA biogenesis confers resistance to ER stress-induced cell death upstream of the mitochondrion.

Disruption of microRNA biogenesis confers resistance to ER stress-induced cell death upstream of the mitochondrion.

Global downregulation of microRNAs (miRNAs) is a common feature of human tumors and has been shown to enhance cancer progression. Several components of the miRNA biogenesis machinery (XPO5, DICER and TRBP) have been shown to act as haploinsufficient tumor suppressors. How the deregulation of miRNA b...

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Bibliographic Details
Main Authors: Karen Cawley, Susan E Logue, Adrienne M Gorman, Qingping Zeng, John Patterson, Sanjeev Gupta, Afshin Samali
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23977393/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23977393/?tool=EBI

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