Identification of hnRNP-A1 as a pharmacodynamic biomarker of type I PRMT inhibition in blood and tumor tissues

Identification of hnRNP-A1 as a pharmacodynamic biomarker of type I PRMT inhibition in blood and tumor tissues

Abstract Arginine methylation has been recognized as a post-translational modification with pleiotropic effects that span from regulation of transcription to metabolic processes that contribute to aberrant cell proliferation and tumorigenesis. This has brought significant attention to the developmen...

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Bibliographic Details
Main Authors: Paul B. Noto, Timothy W. Sikorski, Francesca Zappacosta, Craig D. Wagner, Rocio Montes de Oca, Matthew E. Szapacs, Roland S. Annan, Yan Liu, Charles F. McHugh, Helai P. Mohammad, Steven P. Piccoli, Caretha L. Creasy
Format: Article
Language:English
Published: Nature Publishing Group 2020-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-78800-6

Internet

https://doi.org/10.1038/s41598-020-78800-6

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