Development of an Antigen-DNAzyme Based Probe for a Direct Antibody-Antigen Assay Using the Intrinsic DNAzyme Activity of a Daunomycin Aptamer

Development of an Antigen-DNAzyme Based Probe for a Direct Antibody-Antigen Assay Using the Intrinsic DNAzyme Activity of a Daunomycin Aptamer

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G-Quadruplex (G-4) structures are formed when G-rich DNA sequences fold into intra- or intermolecular four-stranded structures in the presence of metal ions. G-4-hemin complexes are often effective peroxidase-mimicking DNAzymes that are applied in many detection systems. This work reports the appli...

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Bibliographic Details
Main Authors: Noorsharmimi Omar, Qiuting Loh, Gee Jun Tye, Yee Siew Choong, Rahmah Noordin, Jörn Glökler, Theam Soon Lim
Format: Article
Language:English
Published: MDPI AG 2013-12-01
Series:Sensors
Subjects:
G-quadruplex
DNAzyme
gold nanoparticles
antibody
Online Access:http://www.mdpi.com/1424-8220/14/1/346

Internet

http://www.mdpi.com/1424-8220/14/1/346

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