Metformin attenuates silica-induced pulmonary fibrosis via AMPK signaling

Metformin attenuates silica-induced pulmonary fibrosis via AMPK signaling

Abstract Background Silicosis is one of the most common occupational pulmonary fibrosis caused by respirable silica-based particle exposure, with no ideal drugs at present. Metformin, a commonly used biguanide antidiabetic agent, could activate AMP-activated protein kinase (AMPK) to exert its pharma...

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Bibliographic Details
Main Authors: Demin Cheng, Qi Xu, Yue Wang, Guanru Li, Wenqing Sun, Dongyu Ma, Siyun Zhou, Yi Liu, Lei Han, Chunhui Ni
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Journal of Translational Medicine
Subjects:
Occupational pulmonary fibrosis
Metformin
Epithelial-mesenchymal transition
Fibroblast-myofibroblast transition
Online Access:https://doi.org/10.1186/s12967-021-03036-5

Internet

https://doi.org/10.1186/s12967-021-03036-5

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