Monomeric C-Reactive Protein in Serum With Markedly Elevated CRP Levels Shares Common Calcium-Dependent Ligand Binding Properties With an in vitro Dissociated Form of C-Reactive Protein

Monomeric C-Reactive Protein in Serum With Markedly Elevated CRP Levels Shares Common Calcium-Dependent Ligand Binding Properties With an in vitro Dissociated Form of C-Reactive Protein

A monomeric form of C-reactive protein (CRP) which precipitates with cell wall pneumococcal C polysaccharide (CWPS) and retains the ability to reversibly bind to its ligand phosphocholine has been produced through urea-induced dissociation at an optimized concentration of 3 M urea over a 10 weeks pe...

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Bibliographic Details
Main Authors: Robert D. Williams, Jennifer A. Moran, Anthony A. Fryer, Jamie R. Littlejohn, Harry M. Williams, Trevor J. Greenhough, Annette K. Shrive
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Immunology
Subjects:
monomeric C-reactive protein
serum C-reactive protein
dissociated C-reactive protein
calcium-dependent ligand binding
phosphocholine
C-polysaccharide
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00115/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00115/full

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