Leronlimab, a humanized monoclonal antibody to CCR5, blocks breast cancer cellular metastasis and enhances cell death induced by DNA damaging chemotherapy

Leronlimab, a humanized monoclonal antibody to CCR5, blocks breast cancer cellular metastasis and enhances cell death induced by DNA damaging chemotherapy

Abstract Background Triple-negative breast cancer (BCa) (TNBC) is a deadly form of human BCa with limited treatment options and poor prognosis. In our prior analysis of over 2200 breast cancer samples, the G protein-coupled receptor CCR5 was expressed in > 95% of TNBC samples. A humanized monoclo...

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Bibliographic Details
Main Authors: Xuanmao Jiao, Min Wang, Zhao Zhang, Zhiping Li, Dong Ni, Anthony W. Ashton, Hsin-Yao Tang, David W. Speicher, Richard G. Pestell
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Breast Cancer Research
Subjects:
Leronlimab
CCR5
Metastasis
Breast cancer
Online Access:https://doi.org/10.1186/s13058-021-01391-1

Internet

https://doi.org/10.1186/s13058-021-01391-1

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