A stromal progenitor and ILC2 niche promotes muscle eosinophilia and fibrosis-associated gene expression

A stromal progenitor and ILC2 niche promotes muscle eosinophilia and fibrosis-associated gene expression

Summary: Despite the well-accepted view that chronic inflammation contributes to the pathogenesis of Duchenne muscular dystrophy (DMD), the function and regulation of eosinophils remain an unclear facet of type II innate immunity in dystrophic muscle. We report the observation that group 2 innate ly...

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Bibliographic Details
Main Authors: Jenna M. Kastenschmidt, Gerald Coulis, Philip K. Farahat, Phillip Pham, Rodolfo Rios, Therese T. Cristal, Ali H. Mannaa, Rachel E. Ayer, Rayan Yahia, Archis A. Deshpande, Brandon S. Hughes, Adam K. Savage, Carlee R. Giesige, Scott Q. Harper, Richard M. Locksley, Tahseen Mozaffar, S. Armando Villalta
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Cell Reports
Subjects:
ILC2
type II innate immunity
muscle inflammation
eosinophils
muscular dystrophy
interleukin-5
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721003119

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http://www.sciencedirect.com/science/article/pii/S2211124721003119

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