Modification of platelet proteins by malondialdehyde: prevention by dicarbonyl scavengers[S]

Modification of platelet proteins by malondialdehyde: prevention by dicarbonyl scavengers[S]

The thromboxane synthase converts prostaglandin H2 to thromboxane A2 and malondialdehyde (MDA) in approximately equimolar amounts. A reactive dicarbonyl, MDA forms covalent adducts of amino groups, including the ε-amine of lysine, but the importance of this reaction in platelets was unknown. Utilizi...

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Bibliographic Details
Main Authors: Irene Zagol-Ikapite, Iberia R. Sosa, Denise Oram, Audra Judd, Kalyani Amarnath, Venkataraman Amarnath, Donald Stec, John A. Oates, Olivier Boutaud
Format: Article
Language:English
Published: Elsevier 2015-11-01
Series:Journal of Lipid Research
Subjects:
mass spectrometry
thromboxane synthase
cross-link
metabolic syndrome
sickle cell disease
nonsteroidal anti-inflammatory drug
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520354882

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http://www.sciencedirect.com/science/article/pii/S0022227520354882

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