Glial activation is associated with l-DOPA induced dyskinesia and blocked by a nitric oxide synthase inhibitor in a rat model of Parkinson's disease

Glial activation is associated with l-DOPA induced dyskinesia and blocked by a nitric oxide synthase inhibitor in a rat model of Parkinson's disease

l-3, 4-dihydroxyphenylalanine (l-DOPA) is the most effective treatment for Parkinson's disease but can induce debilitating abnormal involuntary movements (dyskinesia). Here we show that the development of l-DOPA-induced dyskinesia in the rat is accompanied by upregulation of an inflammatory cas...

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Bibliographic Details
Main Authors: Mariza Bortolanza, Roberta Cavalcanti-Kiwiatkoski, Fernando E. Padovan-Neto, Célia Aparecida da-Silva, Miso Mitkovski, Rita Raisman-Vozari, Elaine Del-Bel
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Neurobiology of Disease
Subjects:
GFAP
OX-42
iNOS
Glial cells
6-OHDA lesion
Neuroinflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114003301

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http://www.sciencedirect.com/science/article/pii/S0969996114003301

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