PML/RARa Interferes with NRF2 Transcriptional Activity Increasing the Sensitivity to Ascorbate of Acute Promyelocytic Leukemia Cells

PML/RARa Interferes with NRF2 Transcriptional Activity Increasing the Sensitivity to Ascorbate of Acute Promyelocytic Leukemia Cells

NRF2 (NF-E2 p45-related factor 2) orchestrates cellular adaptive responses to stress. Its quantity and subcellular location is controlled through a complex network and its activity increases during redox perturbation, inflammation, growth factor stimulation, and energy fluxes. Even before all-trans...

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Bibliographic Details
Main Authors: Cristina Banella, Gianfranco Catalano, Serena Travaglini, Mariadomenica Divona, Silvia Masciarelli, Gisella Guerrera, Francesco Fazi, Francesco Lo-Coco, Maria Teresa Voso, Nelida Ines Noguera
Format: Article
Language:English
Published: MDPI AG 2019-12-01
Series:Cancers
Subjects:
acute promyelocytic leukemia
pml/rara
nrf2
<i>hmox1</i>
ascorbate
ros
Online Access:https://www.mdpi.com/2072-6694/12/1/95

Internet

https://www.mdpi.com/2072-6694/12/1/95

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