New castanospermine glycoside analogues inhibit breast cancer cell proliferation and induce apoptosis without affecting normal cells.

New castanospermine glycoside analogues inhibit breast cancer cell proliferation and induce apoptosis without affecting normal cells.

sp²-Iminosugar-type castanospermine analogues have been shown to exhibit anti-tumor activity. However, their effects on cell proliferation and apoptosis and the molecular mechanism at play are not fully understood. Here, we investigated the effect of two representatives, namely the pseudo-S- and C-o...

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Bibliographic Details
Main Authors: Ghada Allan, Halima Ouadid-Ahidouch, Elena M Sanchez-Fernandez, Rocío Risquez-Cuadro, José M Garcia Fernandez, Carmen Ortiz-Mellet, Ahmed Ahidouch
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3790671?pdf=render

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http://europepmc.org/articles/PMC3790671?pdf=render

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