Conservation of carbohydrate binding interfaces: evidence of human HBGA selection in norovirus evolution.

Human noroviruses are the major viral pathogens of epidemic acute gastroenteritis. These genetically diverse viruses comprise two major genogroups (GI and GII) and approximately 30 genotypes. Noroviruses recognize human histo-blood group antigens (HBGAs) in a diverse, strain-specific manner. Recentl...

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Bibliographic Details
Main Authors: Ming Tan, Ming Xia, Yutao Chen, Weiming Bu, Rashmi S Hegde, Jarek Meller, Xuemei Li, Xi Jiang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2660415?pdf=render