Mechanistic Models of Inducible Synthetic Circuits for Joint Description of DNA Copy Number, Regulatory Protein Level, and Cell Load

Mechanistic Models of Inducible Synthetic Circuits for Joint Description of DNA Copy Number, Regulatory Protein Level, and Cell Load

Accurate predictive mathematical models are urgently needed in synthetic biology to support the bottom-up design of complex biological systems, minimizing trial-and-error approaches. The majority of models used so far adopt empirical Hill functions to describe activation and repression in exogenousl...

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Bibliographic Details
Main Authors: Lorenzo Pasotti, Massimo Bellato, Davide De Marchi, Paolo Magni
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Processes
Subjects:
mathematical modeling
mechanistic model
synthetic biology
copy number
inducible promoter
cell load
bottom-up design
Online Access:https://www.mdpi.com/2227-9717/7/3/119

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https://www.mdpi.com/2227-9717/7/3/119

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