A novel proteomics approach to epigenetic profiling of circulating nucleosomes

Abstract Alteration of epigenetic modifications plays an important role in human cancer. Notably, the dysregulation of histone post-translational modifications (PTMs) has been associated with several cancers including colorectal cancer (CRC). However, the signature of histone PTMs on circulating nuc...

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Bibliographic Details
Main Authors: Priscilla Van den Ackerveken, Alison Lobbens, Jean-Valery Turatsinze, Victor Solis-Mezarino, Moritz Völker-Albert, Axel Imhof, Marielle Herzog
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-86630-3