Mechanistic Insights on Heme-to-Heme Transmembrane Electron Transfer Within NADPH Oxydases From Atomistic Simulations

Mechanistic Insights on Heme-to-Heme Transmembrane Electron Transfer Within NADPH Oxydases From Atomistic Simulations

NOX5 is a member of the NADPH oxidase family which is dedicated to the production of reactive oxygen species. The molecular mechanisms governing transmembrane electron transfer (ET) that permits to shuttle electrons over the biological membrane have remained elusive for a long time. Using computer s...

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Bibliographic Details
Main Authors: Xiaojing Wu, Jérôme Hénin, Laura Baciou, Marc Baaden, Fabien Cailliez, Aurélien de la Lande
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Chemistry
Subjects:
Marcus theory of electron transfer
reaction free energies
NADPH oxydase
molecular dynamics simulations (MD simulations)
membrane protein
electron tunneling
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2021.650651/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2021.650651/full

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