Fas/FasL Signaling Regulates CD8 Expression During Exposure to Self-Antigens

Fas/FasL Signaling Regulates CD8 Expression During Exposure to Self-Antigens

Activation of self-reactive CD8+ T cells induces a peripheral tolerance mechanism that involves loss of CD8 expression. Because genetic deficiency of Fas and Fasl causes the accumulation of double-negative (DN; CD3+ TCR-αβ+ CD4- CD8-) T cells that have been proposed to derive from CD8+ cells, we dec...

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Bibliographic Details
Main Authors: Giovanna Flores-Mendoza, Noé Rodríguez-Rodríguez, Rosa M. Rubio, Iris K. Madera-Salcedo, Florencia Rosetti, José C. Crispín
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
CD8
CD95
Fas
FasL
tolerance
double negative T cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.635862/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.635862/full

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