The role of DOCK10 in the regulation of the transcriptome and aging

DOCK10, a guanine-nucleotide exchange factor (GEF) for Rac1 and Cdc42 Rho GTPases whose expression is induced by interleukin-4 (IL-4) in B cells, is involved in B cell development and function according to recent studies performed in Dock10-knockout (KO) mice. To investigate whether DOCK10 is involv...

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Bibliographic Details
Main Authors: Natalia Ruiz-Lafuente, Alfredo Minguela, Manuel Muro, Antonio Parrado
Format: Article
Language:English
Published: Elsevier 2019-03-01
Series:Heliyon
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844018355452