Andrographolide modulates OPG/RANKL axis to promote osteoblastic differentiation in MC3T3-E1 cells and protects bone loss during estrogen deficiency in rats

Andrographolide modulates OPG/RANKL axis to promote osteoblastic differentiation in MC3T3-E1 cells and protects bone loss during estrogen deficiency in rats

A decline of estrogen in menopause women is accompanied with increases in many pro-inflammatory cytokines and osteoporosis. Andrographolide (AP), from Andrographis paniculata, which has an anti-inflammatory activity, may have potential to alleviate osteoporosis during estrogen deficiency. Here we re...

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Bibliographic Details
Main Authors: Duangrat Tantikanlayaporn, Patsorn Wichit, Kanoknetr Suksen, Apichart Suksamrarn, Pawinee Piyachaturawat
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Andrographolide
Bone formation
Osteoblast
Osteoporosis
OVX rats
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220309562

Internet

http://www.sciencedirect.com/science/article/pii/S0753332220309562

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