Glutaraldehyde-Modified Recombinant Fel d 1: A Hypoallergen With Negligible Biological Activity but Retained Immunogenicity

Glutaraldehyde-Modified Recombinant Fel d 1: A Hypoallergen With Negligible Biological Activity but Retained Immunogenicity

Background Recombinant allergens are under investigation for replacing allergen extracts in immunotherapy. Site-directed mutagenesis has been suggested as a strategy to develop hypoallergenic molecules that will reduce the risk of side effects. For decades, chemically modified allergen extracts have...

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Bibliographic Details
Main Authors: Serge A. Versteeg, BSc, Ingrid Bulder, BSc, Martin Himly, PhD, Toni M. van Capel, BSc, R. van den Hourt, PhD, Stef J. Koppelman, PhD, Esther C. de Jong, PhD, Fatima Ferreira, PhD, Ronald van Ree, PhD
Format: Article
Language:English
Published: Elsevier 2011-01-01
Series:World Allergy Organization Journal
Online Access:http://www.sciencedirect.com/science/article/pii/S1939455119304296

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http://www.sciencedirect.com/science/article/pii/S1939455119304296

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