Glutaraldehyde-Modified Recombinant Fel d 1: A Hypoallergen With Negligible Biological Activity but Retained Immunogenicity
Background Recombinant allergens are under investigation for replacing allergen extracts in immunotherapy. Site-directed mutagenesis has been suggested as a strategy to develop hypoallergenic molecules that will reduce the risk of side effects. For decades, chemically modified allergen extracts have...
Main Authors: | Serge A. Versteeg, BSc, Ingrid Bulder, BSc, Martin Himly, PhD, Toni M. van Capel, BSc, R. van den Hourt, PhD, Stef J. Koppelman, PhD, Esther C. de Jong, PhD, Fatima Ferreira, PhD, Ronald van Ree, PhD |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2011-01-01
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Series: | World Allergy Organization Journal |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1939455119304296 |
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