Reduction of NADPH-oxidase activity ameliorates the cardiovascular phenotype in a mouse model of Williams-Beuren Syndrome.

Reduction of NADPH-oxidase activity ameliorates the cardiovascular phenotype in a mouse model of Williams-Beuren Syndrome.

A hallmark feature of Williams-Beuren Syndrome (WBS) is a generalized arteriopathy due to elastin deficiency, presenting as stenoses of medium and large arteries and leading to hypertension and other cardiovascular complications. Deletion of a functional NCF1 gene copy has been shown to protect a pr...

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Bibliographic Details
Main Authors: Victoria Campuzano, Maria Segura-Puimedon, Verena Terrado, Carolina Sánchez-Rodríguez, Mathilde Coustets, Mauricio Menacho-Márquez, Julián Nevado, Xosé R Bustelo, Uta Francke, Luis A Pérez-Jurado
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-02-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3271062?pdf=render

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http://europepmc.org/articles/PMC3271062?pdf=render

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