Bioanalytical development and validation of liquid chromatographicâtandem mass spectrometric methods for the quantification of total and free cefazolin in human plasma and cord blood

Objectives: Cefazolin is a commonly prescribed β-lactam antibiotic for prophylaxis against skin infections following surgery, including caesarean sections. Assessment of maternal and neonatal exposure is important for correlating drug concentrations to clinical outcomes. Thus, bioanalytical methods...

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Bibliographic Details
Main Authors: Christopher A. Crutchfield, Mark A. Marzinke
Format: Article
Language:English
Published: Elsevier 2015-04-01
Series:Practical Laboratory Medicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352551715000062