Intracerebroventricular Administration of Amyloid β-protein Oligomers Selectively Increases Dorsal Hippocampal Dialysate Glutamate Levels in the Awake Rat

Intracerebroventricular Administration of Amyloid β-protein Oligomers Selectively Increases Dorsal Hippocampal Dialysate Glutamate Levels in the Awake Rat

Extensive evidence supports an important role for soluble oligomers of the amyloid β-protein (Aβ) in Alzheimer’s Disease pathogenesis. In the present study we combined intracerebroventricular (icv) injections with brain microdialysis technology in the fully conscious rat to assess the eff...

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Bibliographic Details
Main Authors: Sean D. O’Shea, Imelda M. Smith, Michelle M. Cronin, William T. O’Connor, Dominic M. Walsh, Olive M. McCabe
Format: Article
Language:English
Published: MDPI AG 2008-11-01
Series:Sensors
Subjects:
Alzheimer’s Disease
Amyloid β-protein
Microdialysis
Glutamate
GABA
Release
Online Access:http://www.mdpi.com/1424-8220/8/11/7428/

Internet

http://www.mdpi.com/1424-8220/8/11/7428/

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