Associations of mitochondrial genomic variation with corticobasal degeneration, progressive supranuclear palsy, and neuropathological tau measures

Associations of mitochondrial genomic variation with corticobasal degeneration, progressive supranuclear palsy, and neuropathological tau measures

Abstract Mitochondrial health is important in ageing and dysfunctional oxidative phosphorylation (OXPHOS) accelerates ageing and influences neurodegeneration. Mitochondrial DNA (mtDNA) codes for vital OXPHOS subunits and mtDNA background has been associated with neurodegeneration; however, no study...

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Bibliographic Details
Main Authors: Rebecca R. Valentino, Nikoleta Tamvaka, Michael G. Heckman, Patrick W. Johnson, Alexandra I. Soto-Beasley, Ronald L. Walton, Shunsuke Koga, Ryan J. Uitti, Zbigniew K. Wszolek, Dennis W. Dickson, Owen A. Ross
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Acta Neuropathologica Communications
Subjects:
Progressive supranuclear palsy
Corticobasal degeneration
mtDNA
Mitochondrial haplogroups
Tauopathy
Neuropathology
Online Access:http://link.springer.com/article/10.1186/s40478-020-01035-z

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http://link.springer.com/article/10.1186/s40478-020-01035-z

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