Casposase structure and the mechanistic link between DNA transposition and spacer acquisition by CRISPR-Cas

Casposase structure and the mechanistic link between DNA transposition and spacer acquisition by CRISPR-Cas

Key to CRISPR-Cas adaptive immunity is maintaining an ongoing record of invading nucleic acids, a process carried out by the Cas1-Cas2 complex that integrates short segments of foreign genetic material (spacers) into the CRISPR locus. It is hypothesized that Cas1 evolved from casposases, a novel cla...

Full description

Bibliographic Details
Main Authors: Alison B Hickman, Shweta Kailasan, Pavol Genzor, Astrid D Haase, Fred Dyda
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-01-01
Series:eLife
Subjects:
casposon
transposon
CRISPR-Cas
Cas1
integrase
mobile genetic element
Online Access:https://elifesciences.org/articles/50004

Internet

https://elifesciences.org/articles/50004

Similar Items