Dissecting the Cytochrome P450 OleP Substrate Specificity: Evidence for a Preferential Substrate

Dissecting the Cytochrome P450 OleP Substrate Specificity: Evidence for a Preferential Substrate

The cytochrome P450 OleP catalyzes the epoxidation of aliphatic carbons on both the aglycone 8.8a-deoxyoleandolide (DEO) and the monoglycosylated L-olivosyl-8.8a-deoxyoleandolide (L-O-DEO) intermediates of oleandomycin biosynthesis. We investigated the substrate versatility of the enzyme. X-ray and...

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Bibliographic Details
Main Authors: Giacomo Parisi, Ida Freda, Cécile Exertier, Cristina Cecchetti, Elena Gugole, Gabriele Cerutti, Lucia D’Auria, Alberto Macone, Beatrice Vallone, Carmelinda Savino, Linda Celeste Montemiglio
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Biomolecules
Subjects:
cytochrome P450
CYP107D1
OleP
8.8a-deoxyoleandolide
oleandomycin
preferential substrate
Online Access:https://www.mdpi.com/2218-273X/10/10/1411

Internet

https://www.mdpi.com/2218-273X/10/10/1411

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