Endothelial-Rac1 is not required for tumor angiogenesis unless alphavbeta3-integrin is absent.

Endothelial-Rac1 is not required for tumor angiogenesis unless alphavbeta3-integrin is absent.

Endothelial cell migration is an essential aspect of tumor angiogenesis. Rac1 activity is needed for cell migration in vitro implying a requirement for this molecule in angiogenesis in vivo. However, a precise role for Rac1 in tumor angiogenesis has never been addressed. Here we show that depletion...

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Bibliographic Details
Main Authors: Gabriela D'Amico, Stephen D Robinson, Mitchel Germain, Louise E Reynolds, Gareth J Thomas, George Elia, Garry Saunders, Marcus Fruttiger, Victor Tybulewicz, Georgia Mavria, Kairbaan M Hodivala-Dilke
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-03-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20339539/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20339539/pdf/?tool=EBI

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