Respiratory FimA-Specific Secretory IgA Antibodies Upregulated by DC-Targeting Nasal Double DNA Adjuvant Are Essential for Elimination of Porphyromonas gingivalis

Respiratory FimA-Specific Secretory IgA Antibodies Upregulated by DC-Targeting Nasal Double DNA Adjuvant Are Essential for Elimination of Porphyromonas gingivalis

Our previous studies showed that a combination of a DNA plasmid encoding Flt3 ligand (pFL) and CpG oligodeoxynucleotides 1826 (CpG ODN) (FL/CpG) as a nasal adjuvant provoked antigen-specific immune responses. In this study, we investigated the efficacy of a nasal vaccine consisting of FimA as the st...

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Bibliographic Details
Main Authors: Kosuke Kataoka, Shigetada Kawabata, Kayo Koyanagi, Yoshiya Hashimoto, Tatsuro Miyake, Kohtaro Fujihashi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
nasal vaccine
recombinant FimA (rFimA)
dendritic cells (DCs)
double DNA adjuvant
mucosal IgA
Porphyromonas gingivalis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.634923/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.634923/full

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