Kineret®/IL-1ra blocks the IL-1/IL-8 inflammatory cascade during recombinant Panton Valentine Leukocidin-triggered pneumonia but not during S. aureus infection.

Kineret®/IL-1ra blocks the IL-1/IL-8 inflammatory cascade during recombinant Panton Valentine Leukocidin-triggered pneumonia but not during S. aureus infection.

<h4>Objectives</h4>Community-acquired Staphylococcus aureus necrotizing pneumonia is a life-threatening disease. Panton Valentine Leukocidin (PVL) has been associated with necrotizing pneumonia. PVL triggers inflammasome activation in human macrophages leading to IL-1β release. IL-1β act...

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Bibliographic Details
Main Authors: Delphine Labrousse, Magali Perret, Davy Hayez, Sonia Da Silva, Cédric Badiou, Florence Couzon, Michèle Bes, Pascal Chavanet, Gérard Lina, François Vandenesch, Delphine Croisier-Bertin, Thomas Henry
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24905099/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24905099/?tool=EBI

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