Trio Haploinsufficiency Causes Neurodevelopmental Disease-Associated Deficits

Trio Haploinsufficiency Causes Neurodevelopmental Disease-Associated Deficits

Summary: Heterozygous coding mutations in TRIO are associated with neurodevelopmental disorders, including autism, schizophrenia, bipolar disorder, and epilepsy, and impair TRIO’s biochemical activities. To model mutant alleles, we ablated one or both Trio alleles from excitatory neurons in the cort...

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Bibliographic Details
Main Authors: Sara Marie Katrancha, Juliana E. Shaw, Amy Y. Zhao, Samuel A. Myers, Alexandra R. Cocco, Amanda T. Jeng, Minsheng Zhu, Christopher Pittenger, Charles A. Greer, Steven A. Carr, Xiao Xiao, Anthony J. Koleske
Format: Article
Language:English
Published: Elsevier 2019-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719301925

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http://www.sciencedirect.com/science/article/pii/S2211124719301925

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