The Design and Development of a Multi-HBV Antigen Encoded in Chimpanzee Adenoviral and Modified Vaccinia Ankara Viral Vectors; A Novel Therapeutic Vaccine Strategy against HBV

The Design and Development of a Multi-HBV Antigen Encoded in Chimpanzee Adenoviral and Modified Vaccinia Ankara Viral Vectors; A Novel Therapeutic Vaccine Strategy against HBV

Chronic hepatitis B virus (HBV) infection affects 257 million people globally. Current therapies suppress HBV but viral rebound occurs on cessation of therapy; novel therapeutic strategies are urgently required. To develop a therapeutic HBV vaccine that can induce high magnitude T cells to all major...

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Bibliographic Details
Main Authors: Senthil K. Chinnakannan, Tamsin N. Cargill, Timothy A. Donnison, M. Azim Ansari, Sarah Sebastian, Lian Ni Lee, Claire Hutchings, Paul Klenerman, Mala K. Maini, Tom Evans, Eleanor Barnes
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Vaccines
Subjects:
Hepatitis B virus (HBV)
therapeutic HBV vaccine
T cell vaccine
chimpanzee adenovirus
ChAd
ChAdOx1
Online Access:https://www.mdpi.com/2076-393X/8/2/184

Internet

https://www.mdpi.com/2076-393X/8/2/184

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