Immunosenescence Is Associated With Altered Gene Expression And Epigenetic Regulation In Primary And Secondary Immune Organs

Immunosenescence Is Associated With Altered Gene Expression And Epigenetic Regulation In Primary And Secondary Immune Organs

Deterioration of the immune system (immunosenescence) with age is associated with an increased susceptibility to infection, autoimmune disease and cancer, and reduced responsiveness to vaccination. Immunosenescence entails a reduced supply of naïve T cells from the thymus and increased spec...

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Bibliographic Details
Main Authors: Corinne eSidler, Rafal eWoycicki, Yaroslav eIlnytskyy, Gerlinde eMetz, Igor eKovalchuk, Olga eKovalchuk
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-10-01
Series:Frontiers in Genetics
Subjects:
Aging
DNA Methylation
immunosenescence
gene expression profile
histone modification
genome instability
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00211/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00211/full

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