Tetrandrine may treat membranous glomerulopathy via P13K/Akt signaling pathway regulation: therapeutic mechanism validation using Heymann nephritis rat model

Tetrandrine may treat membranous glomerulopathy via P13K/Akt signaling pathway regulation: therapeutic mechanism validation using Heymann nephritis rat model

Membranous glomerulopathy (MGN) is an autoimmune kidney disease that is the primary cause of nephrotic syndrome (NS) in adults. Tetrandrine, a bisbenzylisoquinoline alkaloid, is known to have numerous pharmacological effects. In this study, network pharmacology analysis and experimental validation w...

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Bibliographic Details
Main Authors: Jiazhen Yin, Jiazhen Lin, Jin Yu, Xia Wei, Bin Zhu, Caifeng Zhu
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Bioengineered
Subjects:
tetrandrine
membranous glomerulopathy
network pharmacology
molecular mechanism
Online Access:http://dx.doi.org/10.1080/21655979.2021.1973862

Internet

http://dx.doi.org/10.1080/21655979.2021.1973862

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