Catastrophic NAD+ depletion in activated T lymphocytes through Nampt inhibition reduces demyelination and disability in EAE.

Catastrophic NAD+ depletion in activated T lymphocytes through Nampt inhibition reduces demyelination and disability in EAE.

Nicotinamide phosphoribosyltransferase (Nampt) inhibitors such as FK866 are potent inhibitors of NAD(+) synthesis that show promise for the treatment of different forms of cancer. Based on Nampt upregulation in activated T lymphocytes and on preliminary reports of lymphopenia in FK866 treated patien...

Full description

Bibliographic Details
Main Authors: Santina Bruzzone, Floriana Fruscione, Sara Morando, Tiziana Ferrando, Alessandro Poggi, Anna Garuti, Agustina D'Urso, Martina Selmo, Federica Benvenuto, Michele Cea, Gabriele Zoppoli, Eva Moran, Debora Soncini, Alberto Ballestrero, Bernard Sordat, Franco Patrone, Raul Mostoslavsky, Antonio Uccelli, Alessio Nencioni
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-11-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2774509?pdf=render

Internet

http://europepmc.org/articles/PMC2774509?pdf=render

Similar Items