Melatonin Ameliorates Inflammation and Oxidative Stress by Suppressing the p38MAPK Signaling Pathway in LPS-Induced Sheep Orchitis

Melatonin Ameliorates Inflammation and Oxidative Stress by Suppressing the p38MAPK Signaling Pathway in LPS-Induced Sheep Orchitis

Gram-negative bacterial infections of the testis can lead to infectious orchitis, which negatively influences steroid hormone synthesis and spermatogenesis. Lipopolysaccharide (LPS), a major component of the Gram-negative bacterial cell wall, acts via toll like receptors 4 (TLR4) to trigger innate i...

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Bibliographic Details
Main Authors: Shou-Long Deng, Bao-Lu Zhang, Russel J. Reiter, Yi-Xun Liu
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Antioxidants
Subjects:
melatonin
TLR4
testicular macrophages
p38MAPK
sheep
Online Access:https://www.mdpi.com/2076-3921/9/12/1277

Internet

https://www.mdpi.com/2076-3921/9/12/1277

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