DNA Methylation Cancer Biomarkers: Translation to the Clinic

DNA Methylation Cancer Biomarkers: Translation to the Clinic

Carcinogenesis is accompanied by widespread DNA methylation changes within the cell. These changes are characterized by a globally hypomethylated genome with focal hypermethylation of numerous 5’-cytosine-phosphate-guanine-3’ (CpG) islands, often spanning gene promoters and first exons. Many of thes...

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Bibliographic Details
Main Authors: Warwick J. Locke, Dominic Guanzon, Chenkai Ma, Yi Jin Liew, Konsta R. Duesing, Kim Y.C. Fung, Jason P. Ross
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Genetics
Subjects:
DNA methylation
diagnostic
translation
cancer
epigenetics
liquid biopsy
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.01150/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2019.01150/full

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