Whole exome sequencing in adult-onset hearing loss reveals a high load of predicted pathogenic variants in known deafness-associated genes and identifies new candidate genes

Whole exome sequencing in adult-onset hearing loss reveals a high load of predicted pathogenic variants in known deafness-associated genes and identifies new candidate genes

Abstract Background Deafness is a highly heterogenous disorder with over 100 genes known to underlie human non-syndromic hearing impairment. However, many more remain undiscovered, particularly those involved in the most common form of deafness: adult-onset progressive hearing loss. Despite several...

Full description

Bibliographic Details
Main Authors: Morag A. Lewis, Lisa S. Nolan, Barbara A. Cadge, Lois J. Matthews, Bradley A. Schulte, Judy R. Dubno, Karen P. Steel, Sally J. Dawson
Format: Article
Language:English
Published: BMC 2018-09-01
Series:BMC Medical Genomics
Subjects:
Hearing loss
Whole exome sequencing
Deafness
Online Access:http://link.springer.com/article/10.1186/s12920-018-0395-1

Internet

http://link.springer.com/article/10.1186/s12920-018-0395-1

Similar Items