The dsRBP and Inactive Editor ADR-1 Utilizes dsRNA Binding to Regulate A-to-I RNA Editing across the C. elegans Transcriptome

The dsRBP and Inactive Editor ADR-1 Utilizes dsRNA Binding to Regulate A-to-I RNA Editing across the C. elegans Transcriptome

Inadequate adenosine-to-inosine editing of noncoding regions occurs in disease but is often uncorrelated with ADAR levels, underscoring the need to study deaminase-independent control of editing. C. elegans have two ADAR proteins, ADR-2 and the theoretically catalytically inactive ADR-1. Using high-...

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Bibliographic Details
Main Authors: Michael C. Washburn, Boyko Kakaradov, Balaji Sundararaman, Emily Wheeler, Shawn Hoon, Gene W. Yeo, Heather A. Hundley
Format: Article
Language:English
Published: Elsevier 2014-02-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471400028X

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http://www.sciencedirect.com/science/article/pii/S221112471400028X

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