Targeting Multiple Mitochondrial Processes by a Metabolic Modulator Prevents Sarcopenia and Cognitive Decline in SAMP8 Mice

Targeting Multiple Mitochondrial Processes by a Metabolic Modulator Prevents Sarcopenia and Cognitive Decline in SAMP8 Mice

The age-dependent declines of skeletal muscle and cognitive functions often coexist in elderly subjects. The underlying pathophysiological mechanisms share common features of mitochondrial dysfunction, which plays a central role in the development of overt sarcopenia and/or dementia. Dietary supplem...

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Bibliographic Details
Main Authors: Dario Brunetti, Emanuela Bottani, Agnese Segala, Silvia Marchet, Fabio Rossi, Fiorenza Orlando, Marco Malavolta, Michele O. Carruba, Costanza Lamperti, Mauro Provinciali, Enzo Nisoli, Alessandra Valerio
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Pharmacology
Subjects:
essential amino acids
aging
sarcopenia
cognitive impairment
tricarboxylic acid cycle
mitochondrial respiratory chain
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.01171/full

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https://www.frontiersin.org/article/10.3389/fphar.2020.01171/full

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