Integrative Multi-Omics Analysis in Calcific Aortic Valve Disease Reveals a Link to the Formation of Amyloid-Like Deposits

Integrative Multi-Omics Analysis in Calcific Aortic Valve Disease Reveals a Link to the Formation of Amyloid-Like Deposits

Calcific aortic valve disease (CAVD) is the most prevalent valvular heart disease in the developed world, yet no pharmacological therapy exists. Here, we hypothesize that the integration of multiple omic data represents an approach towards unveiling novel molecular networks in CAVD. Databases were s...

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Bibliographic Details
Main Authors: Marina A. Heuschkel, Nikolaos T. Skenteris, Joshua D. Hutcheson, Dewy D. van der Valk, Juliane Bremer, Philip Goody, Jesper Hjortnaes, Felix Jansen, Carlijn V.C. Bouten, Antoon van den Bogaerdt, Ljubica Matic, Nikolaus Marx, Claudia Goettsch
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cells
Subjects:
calcific aortic valve disease
multi-omics integration
transcriptomics
proteomics
amyloid structures
Online Access:https://www.mdpi.com/2073-4409/9/10/2164

Internet

https://www.mdpi.com/2073-4409/9/10/2164

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