Whole Pichia pastoris yeast expressing measles virus nucleoprotein as a production and delivery system to multimerize Plasmodium antigens.

Whole Pichia pastoris yeast expressing measles virus nucleoprotein as a production and delivery system to multimerize Plasmodium antigens.

Yeasts are largely used as bioreactors for vaccine production. Usually, antigens are produced in yeast then purified and mixed with adjuvants before immunization. However, the purification costs and the safety concerns recently raised by the use of new adjuvants argue for alternative strategies. To...

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Bibliographic Details
Main Authors: Daria Jacob, Claude Ruffie, Myriam Dubois, Chantal Combredet, Rogerio Amino, Pauline Formaglio, Olivier Gorgette, Gérard Pehau-Arnaudet, Charline Guery, Odile Puijalon, Jean-Christophe Barale, Robert Ménard, Frédéric Tangy, Monica Sala
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3903550?pdf=render

Internet

http://europepmc.org/articles/PMC3903550?pdf=render

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